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Research

Research Mission

The Foundation focuses on the long recognized and newly defined group of individuals with posttreatment Lyme syndrome [1]. The goal is to clearly define and understand the cause of disabling symptoms these patients may suffer and improve their diagnosis, treatment, and health outcomes

[1] Post-Lyme disease syndrome, post-treatment chronic Lyme disease and chronic Lyme disease are names used by different medical organizations at different times that generally refer to the same group of patients. It should be noted that the use of Post-Lyme disease syndrome by the Foundation does not imply an endorsement by this Foundation of any one exclusive view regarding causation, diagnosis, or treatment.

Current Study
SLICE Study

SLICE is a landmark study sponsored by LymeMD. A collaborative initiative with the division of Rheumatology at Johns Hopkins, the study examines the impact of Lyme disease on the human immune system and on patient health. Read entire article Note: we are still enrolling patients for the Slice Study. See requirements to participate.

Abstracts Presented at National Meetings about the Slice Study
  • Temporal patterns of early cytokine immune response to infection with B burgdorferi Aucott J, Schwarzwalder A, Miagkov A, Soloski M. Presented at the American Society for Tropical Medicine and Hygiene meetings, November 19-22, 2009. Read entire article
  • Post-Lyme syndrome, an emerging complication of acute infection with Borrelia burgdorferi Schwarzwalder A, Johnson-Greene D, Aucott J. Presented at the International Conference on Emerging Infectious Diseases, July 11-15, 2010. See chart
  • Another Difference between Boys and Girls: Sex-Based Differences in Lyme Disease L. A. Crowder, V. A. Yedlin, M. Soloski, J. N. Aucott See Chart
  • T-cell Immunophenotyping in Early Lyme Disease L. A. Crowder, J. N. Aucott, M. Soloski See Chart
Note: These abstracts describe the SLICE Study, a five-year prospective cohort study conducted through Johns Hopkins Green Spring/Johns Hopkins Bayview examining symptom prevalence, risk factors, natural history, and biomarkers associated with the development of persistent symptoms following exposure to Lyme disease.
Publications
  • Diagnostic Challenges of Early Lyme Disease: Lessons from a Community Case Series John Aucott, Candis Morrison, Beatriz Munoz, Peter C Rowe, Alison Schwarzwalder and Sheila K West. BMC Infectious Diseases 2009, 9:79 Accepted: 1 June 2009.
    This manuscript describes the variability in the presenting symptoms of Lyme disease and difficulty with its diagnosis in the community-based practice of medicine. It shows physicians’ current, widespread difficulty in making accurate diagnosis and treatment decisions in early Lyme. Read entire article
  • The Utility of “Google Trends for Epidemiological Research: Lyme Disease as an Example Ari Seifter, Alison Schwarzwalder, Kate Geis, John Aucott Geospatial Health 4(2), 2010, pp. 135-137. Article examines the potential of the Internet for monitoring epidemics of disease such as Lyme. Read entire article
  • Unusual Presentation of Lyme Disease: Horner Syndrome with Negative Serology Candis Morrison, PhD, CRNP, Ari Seifter, and John N. Aucott, MD. J Am Board Fam Med 2009;22:219 –222. This article highlights an unusual presentation that most physicians would not consider to be a result of Lyme disease. Read entire article
  • Sex Differences in the Clinical and Serologic Presentation of Early Lyme Disease: Results From a Retrospective Review Alison Schwarzwalder, MPH; Michael F. Schneider, MS; Alison Lydecker, MPH; and John N. Aucott, MD. GENDER MEDICINE/VOL. 7, NO. 4, 2010. This paper shows for the first time that women’s antibody responses used to diagnose Lyme disease may not be equivalent to those seen in men. Read entire article
  • Post-treatment Lyme Disease syndrome symptomatology and the impact on life functioning: is there something here? John N. Aucott, Alison W. Rebman, Lauren A. Crowder, & Kathleen B. Kortte QUALITY OF LIFE RESEARCH/Published online: 01 February 2012. This study aims to describe a cohort of participants with early, untreated Lyme disease, and characterize post-antibiotic treatment symptoms and functional impact of post-treatment Lyme disease syndrome over time.. Read entire article
  • Research Article: Bull’s-Eye and Nontarget Skin Lesions of Lyme Disease:An Internet Survey of Identification of Erythema Migrans John N. Aucott, Lauren A.Crowder, Victoria Yedlin, and Kathleen B. Kortte Dermatology Research and Practice, Volume 2012, Article ID 451727, 6 pages doi:10.1155/2012/451727 The results of this survey demonstrate that individuals are unfamiliar with the atypical skin manifestations of early Lyme disease.Read entire article
  • Letters: Emerging Infectious Diseases: Atypical Erythema Migrans in Patients with PCR-Positive Lyme Disease S.E. Schutzer; B.W. Berger; J.G. Krueger; M.W. Eshoo; D.J. Ecker; J.N. Aucott. Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 19, No. 5, May 2013 This report re-emphasizes that the majority of proven cases of erythema migrans do not have the text book “bull’s eye” appearance and therefor may be harder for patients and physicians to recognize as a sign of early Lyme disease.Read entire article
  • Research Article: Development of a foundation for a case definition of post-treatment Lyme disease syndrome John N. Aucott, Lauren A.Crowder, and Kathleen B. Kortte  .International Journal of Infectious Diseases 17 (2013) This article describes the initial findings of the SLICE Study, showing results from the first prospective controlled study in the United States designed to specifically measure symptom and health related quality of life outcomes after the antibiotic treatment of early Lyme disease. Read entire article
  • Direct Molecular Detection and Genotyping of Borrelia burgdorferi from Whole Blood of Patients with Early Lyme Disease Mark W. Eshoo, Christopher C. Crowder, Alison W. Rebman, Megan A. Rounds, Heather E. Matthews, John M. Picuri, Mark J. Soloski, David J. Ecker, Steven E. Schutzer, John N. Aucott Published: PLoS ONE | www.plosone.org -- May 2012 | Volume 7 | Issue 5 | e36825 This research collaboration shows that new state of the art methods can accurately detect the minute amount of DNA of the bacteria Borrelia burgdorferi in the blood stream of patients with early untreated Lyme disease Read entire article
  • Research Article: Probable late lyme disease: a variant manifestation of untreated Borrelia burgdorferi infection John N. Aucott, Ari Seifter, and Alison W Rebman BMC Infectious Diseases 2012, 12:173 This review of patients seen in the community practice of medicine shows that some patients with untreated late Lyme disease may have only chronic symptoms and do not have the classic objective findings of Lyme arthritis or nerve damage. Read entire article